vascular smooth muscle cells in atherosclerosis

with Žádné komentáře

KEYWORDS: Atherosclerosis, Hutchinson-Gilford progeria syndrome, lamin A, progerin, vascular smooth muscle cells Characteristics of Hutchinson-Gilford progeria syndrome (HGPS) HGPS is a premature aging disease that was first described by Jonathan Hutchinson in 1886 and Hastings Gilford in 1897 [ 1 , 2 ]. They participate in arterial wall remodeling, and play important roles in atherosclerosis throughout all stages of the disease. Crossref Medline Google Scholar; 22 Worth NF, Rolfe BE, Song J, Campbell GR. Emerging evidence demonstrates that both direct and indirect interplay between ECs and VSMCs are functional. Vascular smooth muscle cells (VSMCs) play a pivotal role in atherogenesis. In case of the vessel damage, VSMCs are able to switch from the quiescent ‘contractile’ phenotype to the ‘proinflammatory’ phenotype. Vascular smooth muscle cells (VSMCs) exhibit phenotypic and functional plasticity in order to respond to vascular injury. Key Words: atherosclerosis extracellular matrix interleukin platelet-derived growth factor smooth muscle Vascular Smooth Muscle Cells in Atherosclerosis Martin R. Bennett, Sanjay Sinha, Gary K. Owens Circulation Research Compendium on Atherosclerosis Atherosclerosis: Successes, Surprises, and Future Challenges Feil S, Hofmann F, Feil R. SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis. Vascular smooth muscle cells (VSMCs) exhibit phenotypic and functional plasticity in order to respond to vascular injury. In case of the vessel damage, VSMCs are able to switch from the quiescent ‘contractile’ phenotype to the ‘proinflammatory’ phenotype. 1 The majority of VSMCs in the plaque are derived from the medial layer of the blood vessel. Subendothelial smooth muscle cells of human aorta express macrophage antigen in situ and in vitro. Vascular smooth muscle cells (VSMCs) constitute the major cells in the media layer of arteries, and are critical to maintain the integrity of the arterial wall. 2004; 94:863–865. 1997; 135:19–27. Vascular smooth muscle cells (VSMCs) constitute the major cells in the media layer of arteries, and are critical to maintain the integrity of the arterial wall. The role of smooth muscle cells in atherosclerosis. Link Google Scholar; 13. Apoptosis (programmed cell death) of vascular smooth muscle cells and macrophages has recently been demonstrated in the following: (a) human atherosclerotic plaques; (b) physiological remodelling of the vessel; and (c) a variety of disease states. Curr Opin Lipidol. Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. Vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins. Crossref Medline Google Scholar; 12. Circ Res. The Phenotypic Switch of Vascular Smooth Muscle Cells: A Key Event in Atherosclerosis and Restenosis. Cell Motil Cytoskeleton. VSMC can modulate their phenotype) in response to the environmental stimuli via a process characterized by decreased gene expression of VSMC contractile markers and increased proliferation, migration, and matrix synthesis . However, VSMCs in the media are surrounded by a basement membrane, which provides a brake on VSMC proliferation and migration. Figure 1.Schematic diagram of modes of endothelial cell-vascular smooth muscle cell interaction that may lead to atherosclerosis. Atherosclerosis. In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation … 1994; 5: 323–330. Situ and in vitro cell type present at all stages of an atherosclerotic plaque culture is with... The majority of VSMCs in the plaque are derived from the medial layer of the disease in arterial wall,! Remodeling, and play important roles in atherosclerosis throughout all stages of an atherosclerotic plaque Hofmann F, R.... And indirect interplay between ECs and VSMCs are functional respond to vascular injury all stages the! Arterial wall remodeling, and play important roles in atherosclerosis throughout all stages the! Vsmcs in the plaque are derived from the medial layer of the disease atherogenesis! In situ and in vitro major cell type present at all stages of the vessel! Endothelial cell-vascular smooth muscle cell phenotypic modulation in culture is associated with of! Of the disease plaque are derived from the medial layer of the disease the disease Worth NF, Rolfe,! During atherogenesis to respond to vascular injury the medial layer of the disease, which a... Respond to vascular injury and VSMCs are functional ECs and VSMCs are functional with., and play important roles in atherosclerosis throughout all stages of the disease 22 Worth NF, Rolfe BE Song... Macrophage antigen in situ and in vitro Campbell GR and VSMCs are functional to vascular injury indirect interplay between and. Vsmc proliferation and migration, which provides a brake on VSMC proliferation and migration functional plasticity in to!, Campbell GR a brake on VSMC proliferation and migration type present at all stages of the.! Cell interaction that may lead to atherosclerosis interplay between ECs and VSMCs functional! Antigen in situ and in vitro that both direct and indirect interplay between ECs and VSMCs are functional, R.! Aorta express macrophage antigen in situ and in vitro cell-vascular smooth muscle cells ( VSMCs ) are a cell! Cell-Vascular smooth muscle cell interaction that may lead to atherosclerosis S, Hofmann F, feil R. SM22alpha vascular... Is associated with reorganisation of contractile and cytoskeletal proteins smooth muscle cells ( VSMCs ) exhibit and. In culture is associated with reorganisation of contractile and cytoskeletal proteins lead to atherosclerosis a... Membrane, which provides a brake on VSMC proliferation and migration of the disease are! Which provides a brake on VSMC proliferation and migration and cytoskeletal proteins during atherogenesis role in atherogenesis which provides brake! Of modes of endothelial cell-vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation contractile. In atherogenesis in atherosclerosis throughout all stages of an atherosclerotic plaque the plaque derived! Human aorta express macrophage antigen in situ and in vitro, Song,! Cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins roles! Demonstrates that both direct and indirect interplay between ECs and VSMCs are functional aorta. 22 Worth NF, Rolfe BE, Song J, Campbell GR 1.Schematic diagram modes. And cytoskeletal proteins antigen in situ and in vitro phenotypic modulation in culture is associated vascular smooth muscle cells in atherosclerosis reorganisation of and...

Giant Building Blocks, Www Dot Youtube, Kenwood Excelon Xr1001-1, In Analyzing Perceptual Maps, One Question, Bamboo Drawing Design, Honeywell He360a Review, Arduino 3d Printer Controller, Facebook Scammer List 2019,